Drug Provocation Testing in Brugada Syndrome
نویسندگان
چکیده
منابع مشابه
Genetic testing in Brugada syndrome.
Brugada syndrome (BrS) is a hereditary arrhythmic disorder associated with a right ventricular conduction delay and ST-segment elevation in the right precordial leads and syncope and sudden death due to ventricular fibrillation (1). The type 1 Brugada electrocardiographic ECG pattern (coved ST-segment elevations in leads V1 to V3) is a ynamic finding that may be present at baseline or may ecome...
متن کاملFeasibility and outcomes of ajmaline provocation testing for Brugada syndrome in children in a specialist paediatric inherited cardiovascular diseases centre
OBJECTIVES Brugada syndrome (BrS) is an inherited arrhythmia syndrome that causes sudden cardiac death in the young. The class Ia antiarrhythmic ajmaline can be used to provoke the diagnostic ECG pattern. Its use has been established in adults, but little data exist on the ajmaline provocation test in children. This study aims to determine the safety and feasibility of ajmaline provocation test...
متن کاملFlecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A.
BACKGROUND Mutations in SCN5A can result in both long QT type 3 (LQT3) and Brugada syndrome (BrS), and a few mutations have been found to have an overlapping phenotype. Long QT syndrome is characterized by prolonged QT interval, and a prerequisite for a BrS diagnosis is ST elevation in the right precordial leads of the electrocardiogram. METHODS AND RESULTS In a Danish family suffering from l...
متن کاملBrugada syndrome.
Brugada syndrome is a rare cardiac arrhythmia characterized by electrocardiographic right bundle branch block and persistent ST-segment elevation in the right precordial leads. It is associated with ventricular fibrillation and a high risk for sudden cardiac death, predominantly in younger males with structurally normal hearts. Patients can remain asymptomatic, and electrocardiographic patterns...
متن کاملDrug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations.
A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions. DPTs are performed under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself. DPT is sometimes termed controlled challenge or reexposure (1), drug challenge (2), graded (2) or increm...
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ژورنال
عنوان ژورنال: JACC: Clinical Electrophysiology
سال: 2019
ISSN: 2405-500X
DOI: 10.1016/j.jacep.2019.03.003